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This estimand was used to assess the superiority of semaglutide versus placebo for the co-primary and confirmatory secondary endpoints in a predefined hierarchical order

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While some claims based on prior diagnoses may be excluded, the decision enables the MDL to move forward efficiently

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Moreover, the findings are based on a single animal model and cannot yet be generalized to human diabetic encephalopathy without further clinical validation

However, in most cases, the criteria for insurance drug coverage are that the medication is being used for an FDA-approved purpose