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Understanding how these agents work independently is essential before considering their combined use, particularly given that gastrointestinal side effects are among the most common adverse reactions reported with tirzepatide therapy

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I have seen patients with chronic nausea and vomiting on (semaglutide), which can cause dehydration and malnutrition if you cant get enough calories or fluids daily, registered dietitian Emily Rubin, director of clinical dietetics in the division of gastroenterology and hepatology at Thomas Jefferson University Hospital in Philadelphia, previously told TODAY.com

Gastrointestinal Discomfort: Nausea, upset stomach, or mild diarrhea