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Studies show that elevated TMAO decreases mTOR and p70S6K expression, causes hippocampal neuron loss and synaptic ultrastructural damage, and worsens cognitive function in mice, with higher TMAO leading to more severe deficits (Li et al., 2018)

Anti-NMDA receptor antibodies were detected in cerebrospinal fluid

Gentle yet Effective Formulations: Development of "lunchtime peels" or overnight wraps that offer results with minimal downtime

PMID: 29687066

Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

Together, UTHealths press materials and the published ATTAIN2 trial offer regulators and frontline clinicians the data they will lean on as approval decisions move forward