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And I've had individuals in my office where it's pretty apparent that while they've lost a tremendous amount of body weight, a lot of that weight was lean muscle, muscle mass, and that's exactly what you don't want to happen on these medications, and then you have to maybe back off or even give them a break until they can really get back into the drive of exercise

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However, severe or worsening bloating, particularly if accompanied by persistent vomiting, severe abdominal pain (especially if radiating to the back, which may indicate pancreatitis), or inability to tolerate food or fluids, requires prompt medical evaluation

doi: 10.1155/2021/5497346, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 11