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98 In addition, Muc2 gene mutation in mice can induce endoplasmic reticulum stress in intestinal epithelial cells, and the misfolding of intrinsic proteins in the intestinal epithelium triggers the inflammatory response of intestinal epithelial cells, thereby destroying the structure and function of the intestinal barrier in mice and promoting the progression of UC by affecting the intestinal microbiota
224,233 Benfotiamine, a lipid-soluble thiamine derivative, has been shown to activate transketolase activity, thereby redirecting glycolytic intermediates away from the hexosamine pathway
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