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They have also demonstrated that rat brain microvascular endothelial cells can rapidly uptake fluorescence-labeled GLP-1, the event can be blunted with the utilization of the GLP-1R antagonist Exendin (939)

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Despite FAERS limitations (underreporting bias, confounding factors), these findings advocate for tailored monitoring protocolsgradual dose titration, renal/thyroid surveillance in high-risk groups, and long-term vigilance for rare AEs

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Winden KD, Ebrahimi-Fakhari D, Sahin M