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Upon activation, GPER stimulates intracellular signaling cascades, including the PI3K/AKT and MAPK/ERK cascades, which further augment mitochondrial respiratory chain activity and ATP production [218]

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Repeated inadvertent ingestion of supratherapeutic doses may be especially dangerous, due to subacute depletion of hepatic glutathione stores

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Thioredoxin is also required for the microtubule assembling process 11,30 and for the functioning of nucleotide reductases involved in nucleotide synthesis 21

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