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Melatonin could be considered as the first candidate for clinical trials of neuroprotection in preterm infants, thanks to the peculiarity of easily crossing the placental barrier and its effect in improving myelin content and oligodendroglia cell maturation 125,126

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Improved formulation technologies Compounding pharmacies are investing in better sublingual delivery vehicles

Another aspect of the invention is that sequential administration of low doses of a PDE-5 inhibitor and PT-141 for treatment of sexual dysfunction provides a therapeutic effect equal or superior to administration of a high dose of any one single agent without the side effects attendant to administration of a high dose of any one single agent

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M.et al (2009)