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Dose-response network meta-analysis of gastrointestinal adverse events with GLP-1 receptor agonists, 39 randomised trials and 33,354 non-diabetic participants with overweight or obesity

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Glycated hemoglobin A 1c (HbA 1C ) at the onset of diabetes was 11.6% (102.6 mmol/mol)

Many protocols administer both in the same injection session, though in separate syringes and at separate (even if nearby) injection sites

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Notably, this benefit encompassed a 24% reduction in heart failure hospitalizations and a 17% decrease in cardiovascular fatal events