Critical caveat: All FOXO4-DRI data comes from animal models and cell culture
Hydroxocobalamin (Cyanokit) antidote facts
This leads to a shift in TAMs from the pro-inflammatory, cancer-fighting M1 phenotype to the tumor-supporting M2 phenotype
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By inhibiting autophagy, the TP53 mutation, which is less common in hematological cancers than in solid tumors, increases p53 expression and triggers apoptotic responses dependent on p53-upregulated modulator of apoptosis and BAX, leading to AML cell destruction (44)