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As such, it has been linked to the development of autoimmune thyroiditis

Vitamin B12 injections also positively affect mood

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10.1007/s10815-014-0390-1 119

Profound sedation, respiratory depression, coma, and death may result from the concomitant use of hydrocodone bitartrate and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol [e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids]

The clinical evidence is clear, the mechanism is understood, and patients report real symptom relief