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In HPV-induced cancers, the Wnt signaling is activated by HPV E6 and E7 oncoproteins through inhibiting various regulatory factors such as p53, human telomerase reverse transcriptase (hTERT), and protein phosphatase 2A (PP2A) [94]

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Cells were incubated at room temperature for a further 2 h and stimulated with 10 nM GLP-1 or GIP in HEPES-buffered saline (HBSS) containing 107 mM NaCl, 6 mM KCl, 1.2 mM MgSO 4 , 2 mM CaCl 2 , 1.2 mM KH 2 PO 4 , 20 mM HEPES, and 5.5 or 16.7 mM glucose at pH 7.4

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue