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The role of the Wnt pathway in both reactive and nonreactive state of astrocytes has been examined in various studies, with evidence suggesting that it influences astrocytes communication with other cells in the CNS by stimulating the transcription of synaptogenic factors 120
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In autistic patients, the temporal lobe had lower levels of anti-oxidant activity and significantly higher levels of 8-hydroxy-2-deoxyguanosine, a hallmark of oxidatively damaged DNA [80, 136]
