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In human metabolic research 3 , elevated IGF-1 levels correlated with improved muscle energy utilization and reduced fatigue during recovery phases

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A 2012 paper extended these findings into more detailed gastric-dysmotility investigations (PMID 27186127)

Sermorelin and tesamorelin both have histories as FDA-approved compounds for specific clinical contexts, while ipamorelin has only ever been studied as a research compound and is not approved for human use