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The trial sample size was chosen on the basis of the robust efficacy of ARA 290 in a rodent model of neuropathy (12) and from the observations derived from a prior small nonblinded trial of 20 patients with symptoms of SFN who received ARA 290 (2 mg intravenously) for three doses every 2 d over 1 wk (11)

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IGF-1 LR3 , on the other hand, works more directly by promoting cell regeneration and repair at a tissue level

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10.1073/pnas.1525001113 81 HeY.LiS.ZhangW.DaiW.CuiT.WangG.et al (2017)