Lyophilisation removes moisture from the compound to preserve stability during storage and transport
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Although they each have their roles, vitamin B12 works closely with another B vitamin, folate, for the proper function of the nervous system, production of healthy red blood cells, and in S-adenosylmethionine (SAMe), a compound that supports mood and immune function 1
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acnes downregulates its own synthesis pathway of vitamin B12 and upregulates porphyrins, which are known to induce inflammation in acne
Or better yet, consider the reconstitution math before purchasing