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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

Medical conditions: Certain medical conditions, such as cirrhosis of the liver, Crohn's disease, type 2 diabetes, and certain blood disorders, can increase the risk of gallstones

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Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, et al

Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition

Fountoulakis et al., 2023) and recent preclinical studies have shown that exposure to HnB tobacco smoke could be associated with some health concerns typically elicited by traditional smoking (Vivarelli et al., 2022