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Anti-inflammatory signaling downregulation of inflammatory mediators in injury models

After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the cardiac and broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500

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A peptide that survives the stomach still faces this second gauntlet before any mucosal transport