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Common positive reports include reduced joint stiffness and morning pain (likely primarily from weight loss), improved energy levels after initial adjustment, better mood and reduced brain fog, improved sleep quality, and feeling that their autoimmune medications "work better" than before starting tirzepatide

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Perhaps there is a distinction I'm missing between time to clearance of the injected B12 and the half-life of B12 when in plasma

Chandra Shekhar H, Joshua L, Thomas JV

So thanks for sharing that

Importantly, the temporal pattern of these side effects is clinically relevant