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In mice lacking Nav1.6 channels, I NaP currents are reduced by 39%, and I NaR currents are suppressed by 76%, leading to the loss of subthreshold oscillations, impedance resonance, and both spontaneous and evoked rhythmic firing (Enomoto et al., 2006, 2007)

CD44 receptor mediates urate crystal phagocytosis by macrophages and regulates inflammation in A murine peritoneal model of acute gout

Mounjaro (tirzepatide) , on the other hand, is a dual receptor agonist

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