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Four isoforms of human glutaminase are divided into two highly active renal glutaminase types encoded by GLS1 and two low active hepatic glutaminase types encoded by GLS2

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Under homeostatic conditions, Keap1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor Nrf2 by targeting it for ubiquitination and proteasome-dependent degradation

B vitamins are essential for the proper functioning of the nervous system, cardiovascular system, and many other functions