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Vitamin B12 deficiency can lead to pernicious anemia, a form of anemia that can result in irreversible nerve damage known as pernicious neuropathy

Vomiting and diarrhea can lead to dehydration, and the label carries a warning about acute kidney injury due to volume depletion, with postmarketing reports of cases requiring hemodialysis

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In support of a multisynaptic OB to LH pathway, retrograde tracing (Fig