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Participants who maintained weekly injection schedules experienced sustained reductions in hunger signals and achieved weight losses ranging from 16% to 22%, depending on their dose level

At 48 weeks, the Phase 2 trial recorded an average loss of 24.2% total body weight at the highest dose

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This distinguishes AS as a disease characterised by progressive glomerular sclerosis, tubulointerstitial fibrosis, and inflammation, driven by the downstream effects of GBM dysfunction

( A C ) Freely fed mice were injected i.p