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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

Poisson et al., 2021)

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It was also traditionally used for hepatitis and haemorrhoids (1)

No surgery or long recovery time is required, making it a convenient option for those looking to avoid invasive procedures

At higher doses, the vial empties quickly, making larger vials more practical and cost-effective