NICE guidance recommends GLP-1 receptor agonists particularly when BMI 35 kg/m, significant hypoglycaemia risk exists, or cardiovascular protection is desired in patients with established cardiovascular disease
USA 94: 2745-2750
No phase II or III randomised controlled trials have been registered with the EMA, MHRA or FDA
While these medications work to help manage weight and control blood pressure, they work even better when combined with positive lifestyle changes
(11) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11
Understanding these mechanisms provides insight into how this peptide produces its body composition effects