J Clin sleep medicine: JCSM: Off Publ Am Acad Sleep Med
318 In T2DM, insulin resistance in metabolically active tissues, such as muscle, fat, and liver, leads to hyperglycemia and dyslipidemia
Koelwyn, G
OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype
For starters, its only intended for short-term use
The preservation of peptide stability has been observed for at least 28 days after reconstitution.[15] Peptides stored in Reconstitution Solution maintained 98% activity in assays up to 14 days post-reconstitution.[16] 2.3 Microbial Control & Aseptic Handling Benzyl alcohols bacteriostatic action has been well documented in pharmaceutical formulations, especially in multi-use vials, which ensures that peptides do not become contaminated during the study period.[17][18] Multiple use vials of Reconstitution Solution for research have shown reduced microbial load, even after repeated sampling.[19] 2.4 Storage & Stability Considerations While Reconstitution Solution extends the shelf life of reconstituted peptides, its effectiveness relies on proper storage conditions
