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doi: 10.3389/fphar.2022.929262 Received 26 April 2022 Accepted 30 June 2022 Published 12 August 2022 Volume 13 - 2022 Edited by Christoph Reinhardt, Johannes Gutenberg University Mainz, Germany Reviewed by Zeneng Wang, Cleveland Clinic, United States Saravanan Subramaniam, Boston University, United States Updates Copyright 2022 Zixin, Lulu, Xiangchang, Qing, Binjie, Chunyang, Tai and Dongsheng

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GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety ( 2 GLP-1R GLP-1R is a G protein-coupled receptor (Wu et al., 2020) (Figure 1A)

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