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Most people tolerate them incredibly well, and when side effects do pop up, they are usually pretty mild

Glucagon-like peptide-1 receptor (GLP-1) agonists are an effective treatment for controlling blood glucose levels in people with type 2 diabetes, particularly those who do not respond, or stop responding to, first-line treatments, such as metformin

This may have resulted from the timing of the study relative to the COVID-19 pandemic (SURMOUNT-1 and STEP during, ONeil and SCALE Obesity and Prediabetes prior), which may have impacted the reporting of safety events

Biosci Microbiota Food Health 41(3):103111 Vallianou NG, Stratigou T, Tsagarakis S (2019) Metformin and gut microbiota: their interactions and their impact on diabetes

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