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This observation suggests an antimicrobial activation of the immune response, which is linked to dysbiosis

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J Cell Biol 164:341346 Walsh JS, Miwa GT (2011) Bioactivation of drugs: risk and drug design

Folate-Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review

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The activated NF- B rapidly translocated from the cytoplasm into the nucleus, binds to specific DNA sequences, induces the expression of several proinflammatory cytokine genes, and promotes the massive release of proinflammatory cytokines such as TNF- , IL-1, and IL-6 (Xu et al., 2022)