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Iron accumulation, lipid peroxidation, and decreased GPX4 expression, which are characteristic hallmarks of ferroptosis, contribute to inflammation through the induction of oxidative stress and the activation of the high mobility group box-1 protein1-advanced glycosylation end-product-specific receptor signaling pathway and extracellular signal-regulated kinase, respectively [77,78,79]

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doi: 10.1097/01.all.0000173788.73401.69 39 RahmanI.KodeA.BiswasS

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In those cases, a protocol may be discussed alongside relevant assessments such as: Inflammation and cardiometabolic markers Hormone patterns Biological age testing (context-dependent methods) Sleep and recovery tracking 3) Age-Related Resilience Goals This is not about a single symptom