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Because the incidence of AEs was greatest during dose escalation, the disparity in total years of exposure between the two trials could potentially dilute the reported rate of AEs in PIONEER 3 compared with PIONEER 12

N-Acetyl Cystine (NAC) NAC is a potent antioxidant that also promotes detoxification

Biotechnol Appl Biochem 42:6771

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Because the effect is centrally mediated (originating in the brain), it can complement other therapies for sexual performance without relying solely on vascular stimulation