The magnitude of appetite stimulation is dose-dependent and typically most pronounced at higher research doses
4,8 The reference standard to establish allergic potential vs tolerance is drug provocation, or direct oral challenge (DOC) with a test dose of the culprit drug
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van Seventer and Hochberg, 2017) and procedures involving biomaterials or medical devices (Arciola et al., 2018
Disseminated form[edit | edit source] It occurs anywhere on the trunk and mucous membranes