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Gastroenterology 101 :540547

Instead of injecting testosterone directly (which shuts down your own production), peptides nudge your body to make more of its own preserving fertility, testicular size, and the natural feedback loop

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Methods This propensity-score matched cohort study analyzed TriNetX US network data from November 2023 through April 2025

Mechanism of Action GLP-1R agonism enhances glucose-dependent insulin secretion, suppresses glucagon, delays gastric emptying, and reduces appetite GIPR agonism amplifies insulin secretion additively

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Anderson SL, Trujillo JM