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The metabolic modulator trimetazidine triggers autophagy and counteracts stress-induced atrophy in skeletal muscle myotubes

designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

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Glutathione takes hydrogen peroxide made from SOD and turns it into O2, which is oxygen

Funding This work was supported, in part, by funding from TTO/Life Science College 19-2215 at Brigham Young University

doi: 10.1161/STROKEAHA.116.015609 119 MaLChenCZhaoCLiTMaLJiangJet al