Recently report address that GH inhibits DNA damage repair by suppressing ATM and DNA-PKcs activities in colon cells, leading to decreased DNA repair by both HR and NHEJ ( In vivo , injecting hGH to human subjects for 6 weeks results in increased lymphocyte DNA damage, and the damage can last for a long time after hGH withdrawal ( IGF1 Promotes DNA Damage Repair of DNA DBSs IGF1 and IGF1R are necessary for nucleotide excision repair (Strozyk and Kulms, 2013)
MGCA1 can be distinguished from the other forms of MGCA because the levels of 3-methylglutaconic acid are highly elevated, whereas levels of methylglutaric acid are usually only slightly elevated, and there is a high level of 3-hydroxyisovaleric acid excretion which is not seen in the other forms of MGCA
These findings suggest that the observed trend toward benefit is unlikely to be driven by a single biased study, although the overall certainty of evidence remains limited by imprecision and heterogeneity
ChaudhuryCMehnazSRobinsonJMHaytonWLPearlDKRoopenianDCet al
In fact, published data show GHK-Cu can influence the activity of thousands of genesturning on those linked to healing and antioxidant defense, while turning down chronic inflammation and cancer-promoting pathways
it is not always simply the same drug in a different form
