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SFN (MedChemExpress, NJ, USA) was intraperitoneally injected at 5 mg/kg once a day for 7 consecutive days

J Exp Bot 56:921933 Leipner J, Fracheboud Y, Stamp P (1999) Effect of growing-season on the photosynthetic apparatus and leaf antioxidative defenses in two maize genotypes of different chilling tolerance

The high throughput screening campaign of the substance library provided several hit compounds one of those the drug-like aryl sulfonamide 40 that was subsequently optimized into 41 that is a metabolically stable and reversible IRAP inhibitor

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Occasionally, mild discomfort at the injection site or rare allergic sensitivities may occur