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Serious underlying conditions include sepsis (infection spreading through blood), internal bleeding, heart failure, or severe allergic reactions requiring emergency intervention

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In mouse models, PE-22-28 doubled the number of BrdU-positive cells, which are newly born neurons actively incorporating DNA during division

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A clinical trial and in vivo experiment in ApoE -/- mice revealed that IPA was significantly downregulated in CAD patients, correlating with atherosclerotic cardiovascular disease (ASCVD) risk and severity