The oncogenic role of Jagged1/Notch signaling in cancer
Cherries: A traditional gout treatment rich in polyphenol antioxidants, cherries have been shown to reduce the number of acute gout attacks
By promoting the shedding of dead skin cells and encouraging the growth of new, healthy cells, retinol smooths out rough patches and reduces the appearance of blemishes
Miller, [email protected], orcid.org/0000-0002-4743-8187 These authors have contributed equally to this work and share first authorship This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Untreated Controls Preclinical injury models % reduction in healing time Tendon Transection (Rat Achilles model)50% Skin Wound Closure (Alkali burn model)45% Muscle Crush Injury (Rat quadriceps)40% Safety Data Safety Profile from Research What preclinical and early clinical studies report Preclinical Safety Summary LD50Not achieved Acute toxicityNone observed Chronic toxicityNone in 6-month studies Organ toxicityNone detected Human IV pilot (n=2)No adverse effects Cardiac/hepatic/renalNo effects detected Regulatory & Risk Considerations FDA statusUnapproved drug WADA statusBanned since 2022 (S0) Human trialsPhase 1 only Long-term effectsUnknown in humans Pro-angiogenic riskTheoretical unstudied Australia/NZPrescription only No lethal dose was reached in preclinical toxicology studies
Specialised suppliers operating out of established logistical hubssuch as Dubaisignificantly mitigate customs risks
