Because ovulation, clinical pregnancy, time to pregnancy, and live birth were inconsistently defined and sparsely reported across trials, no confirmatory quantitative synthesis or treatment ranking was undertaken for these reproductive outcomes
27 The other RCT found no significant mean differences between B12 and placebo
Same formula, different dose ranges
Joshi GP, LaMasters T, Kindel TL
Glossary BAs Bile Acids CA Cholic Acid CDCA Chenodeoxycholic Acid GCA Glycocholic Acid TCA Taurocholic Acid TCDCA Taurochenodeoxycholic Acid GCDCA Glycochenodeoxycholic Acid LCA Lithocholic Acid DCA Deoxycholic Acid TDCA Taurodeoxycholic Acid GDCA Glycodeoxycholic Acid UDCA Ursodeoxycholic Acid TUDCA Tauroursodeoxycholic Acid GUDCA Glycoursodeoxycholic Acid TLCA Taurolithocholic Acid GLCA Glycolithocholic Acid Tfh T Follicular Helper 3-oxoDCA 3-oxodeoxycholic Acid 3-oxoLCA 3-oxolithocholic Acid 3oxoalloLCA 3oxoallolithocholic acid alloLCA allolithocholic Acid -MCA -muricholic Acid isoLCA Isolithocholic Acid HDCA Hyodeoxycholic Acid isoalloLCA isoallolithocholic Acid isoDCA 3-hydroxydeoxycholic Acid -MCA -muricholic Acid NorUDCA 24-Nor-ursodeoxycolic Acid RORT Retinoic Acid Receptor-related Orphan Receptor-T TGR5 Takeda G protein-coupled receptor 5 CNS1 Conserved Noncoding Sequence 1 CNS3 Conserved Noncoding Sequence 3 VDR Vitamin D Receptor FXR Farnesoid X Receptor NR4A1 Orphan Nuclear Receptor 4A1 TGF- Transforming Growth Factor 3-oxo- 4,6 -LCA 3-oxo- 4,6 -lithocholic Acid HCC Hepatocellular Carcinoma NK Natural Killer T--MCA Tauro--muricholic Acid CREB Cyclic-AMP Response Element-Binding Protein CXCR6 C-X-C Motif Chemokine Receptor 6 CXCL16 C-X-C Motif Chemokine Ligand 16 TNF- Tumor Necrosis Factor IFN- Interferon- Tfh T Follicular Helper RRMS Relapsing-Remitting Multiple Sclerosis IL-17 Interleukin-17A IBD Inflammatory Bowel Disease UC Ulcerative Colitis CD Crohns Disease 7-ketoLCA 7-ketolithocholic acid 12-KLCA 12-ketolithocholic acids CRC colorectal cancer iNOS inducible Nitric Oxide Synthase RA Rheumatoid Arthritis AML Acute Myeloid Leukemia MAIT Mucosa-associated Invariant T CA7S Cholic Acid 7-Sulfate PSC Primary Sclerosing Cholangitis ILC Innate Lymphoid Cell GPCR G protein-coupled receptors 6E-CDCA 6-ethylchenodeoxycholic Acid RORs Retinoid Orphan Receptors DCs Dendritic cells ILC3s Group 3 Innate Lymphoid Cells NKT natural killer T MCA muricholic acid IL1 Interleukin-1 IL6 Interleukin-6 NLRP3 NOD-like receptor pyrin domain containing 3 Treg regulatory T cell SHP small heterodimer partner CYP7A1 cholesterol 7-hydroxylase DSS dextran sulfate sodium FGF15 Fibroblast Growth Factor 15 CAR Constitutive Androstane Receptor hAR human Androgen Receptor LPS lipopolysaccharide JNK c-Jun N-terminal kinase NASH Nonalcoholic Steatohepatitis PBC Primary Biliary Cholangitis OCA obeticholic acid SXR Xenobiotic Receptor PXR Pregnane X Receptor LXR Liver X receptor BSHs Bile Salt Hydrolases HSDHs Hydroxysteroid Hehydrogenases FMT Fecal Microbiota Transplantation NSCLC Nonsmall Cell Lung Cancer CNS Central Nervous System ROS Reactive Oxygen Species PDAC Pancreatic Ductal Adenocarcinoma MAFLD Metabolic Dysfunction-associated Fatty Liver Disease Th17 T helper 17 cells References 1 LynchLEHairABSoniKGYangHGollinsLANarvaez-RivasMet al
doi: 10.3390/jcm8111992 67 ViriliCTrimboliPCentanniM
