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Metabolism Rate Individuals with a faster metabolism will generally process and eliminate phentermine more quickly than those with slower metabolic rates

This means the brain stops defending a higher weight and is comfortable at a lower weight

Glucagon receptor agonism is the defining mechanistic difference: it is thought to increase energy expenditure and reduce liver fat, but it also raises the theoretical risk of transient increases in glucose and heart rate

Faster initial loss is common in people with higher baseline weights or more restricted calorie intake