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(1991) reported that dairy cows experiencing an energy deficiency exhibit reduced IGF-1 and LH concentrations, which results in smaller dominant follicles and delayed ovulation

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doi: 10.1186/s13287-022-02990-1

AMG 133 or Maridebart Cafraglutide, developed by company Amgen Amgen (Amgen, Thousand Oaks, CA, USA), is an optimized drug conjugate containing two GLP-1 analogs coupled to human monoclonal antibody against the GIP receptor

They are fast-acting and effective, but long-term use causes skin thinning, telangiectasia (visible blood vessels), and tachyphylaxis (reduced effectiveness over time)