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On average, tirzepatide has been shown in research to lead to a greater amount of weight loss : People with obesity in clinical trials for tirzepatide lost, on average, 20% of their body weight at week 72 (and about 7 inches off their waistlines), compared with about 14% of their body weight (and about 5 inches off their waistlines) with semaglutide

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Qeadan, F., McCunn, A., & Tingey, B

These medications affect dopamine (happy chemical) release in the brain, altering reward pathway processes

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