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The hyper-inflammatory response caused by SARS-CoV-2 induces the process of immunosenescence, increases endothelial cell damage, and leads to myofibrillar degradation and muscle wasting (sarcopenia) due to mitochondrial dysfunction and autophagy [102]
However, any claims that IGF-1 can promote weight loss are largely theoretical, or based on animal studies and small human studies (14)
PMID: 51 YangJWangZZhangX
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