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Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function

AKT, Protein kinase B (PKB)

Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, et al

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No 72-week obesity trial tested below 5 mg

Bound proteins reduce free Cu to nM range essentially 0% systemic inhibition of either isoform