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The up-regulation of the SOD, GPx, and CAT genes in the DMSO treated Group of rats (Figures 1113), with a concomitant increase in serum and brain of the rats treated with DMSO (Figures 1113), further confirmed that the increase in the enzymatic activities is a result of increased synthesis which is influenced by DMSO

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(28(6)):e13077 doi:10.1111/anec.13077

The treatment of RA with Western medicine still entails severe side effects and drug resistance