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108 In a second clinical study that examined 14 female subjects aged 5368 years who were amenorrheic for 110 years (mean interval, 5 years) that applied a MEP night cream (at 2%) for a total of 20 weeks displayed improvements in: a) skin texture (53%), b) keratoses (21%), and c) skin laxity (15%)

It is not known whether is excreted in human milk

Many plans require pre-authorization or may deny coverage if the indication falls outside their approved list