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Additionally, tirzepatide acts on central appetite regulation pathways in the hypothalamus, leading to reduced caloric intake and significant weight losswith clinical trials showing dose-dependent reductions ranging from approximately 15% at higher doses in the SURMOUNT-1 trial

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Tirzepatide was approved by the FDA for A1c lowering in Type 2 Diabetes in May 2022 Although it has not yet been approved for obesity, tirzepatide demonstrated significant weight reduction when analyzed as the secondary outcome in the SURPASS trials and as the primary outcome in the SURMOUNT I trial

The gold standard is a DEXA scan (dual-energy X-ray absorptiometry)