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10.1007/s00441-011-1275-6 103 LuB.LiJ.GuiM.YaoL.FanM.ZhouX.et al (2022a)

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Second, hyperhomocysteinemia detected only by the oral methionine-loading test (approximately 27% of patients), which might mainly result from an inhibition of the transsulfuration pathway (vitamin B 6 deficiency or heterozygous CBS defect), and which increases the risk 1.5-fold