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It is especially concerning in older individuals, as bone density also naturally falls with age

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87 In the UC rat model, NaHS can promote autophagy by regulating the levels of autophagy-related proteins, including increasing the LC3-II/LC3-I ratio and decreasing the level of p62

Of the older therapies, sulphonylureas, insulin and glitazones are all associated with significant weight gain, whereas metformin is associated with slight weight loss