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Keywords: tirzepatide, GLP-1, GIP, Aib, structureactivity relationship, structurefunction relationship Introduction From GLP-1 Receptor Agonists to Tirzepatide Incretins are hormones that are secreted from the gastrointestinal tract into the circulatory system in response to nutrient ingestion, enhancing glucose-stimulated insulin secretion

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, dorsal thalamus, hippocampus, lateral geniculate body, hypothalamus, dorsal raphe nucleus, substantia nigra, medial anterior olfactory nucleus, lateral caudate, accumbens nucleus, superior olive)) (shown by the very precise alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method) (16, 20)

Nature 435 , 959963 (2005)

10.4088/JCP.21r14328 16 ArnoldF

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